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Tocotrienols: Vitamin E Beyond Tocopherols, 2E

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978 1 4398 8441 6
2.00 LBS
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The first 90 years of vitamin E research has produced prolific and notable discoveries, but until the last few decades, attention has been given mostly to the biological activities and underlying mechanisms of alpha-tocopherol, which we now know is one of more than eight vitamin E isomers.  Currently, the non-tocopherol vitamin E molecule tocotrienol has reached a new measure of research height: more than one-third of all vitamin E tocotrienol research of the last 30 years has been published since 2009.  The thriving field of tocotrienol research gives ground for publication of Tocotrienols: Vitamin E Beyond Tocophenols, Second Edition, a compilation of the latest tocotrienol research in all new chapters.

Here are the highlights:  (1) Established research, including prevention and treatment of cardiovascular disease, metabolic syndrome, and cancer; (2) Emergent research, including angiogenesis, bioavailability, bone health, gastric injury, inflammation, life extention, and skin health; (3) Tocopherol interference with tocotrienol functions; and (4) All new chapters and many new contributors.

Recognized as potent antioxidants, tocotrienols play a role in cholesterol reduction, tumor suppression, reversal of arteriosclerosis, and protection of the heart against oxidative stress.  Compiling contributions from leading researchers, this book overviews tocotrienols and examines their sources, chemistry, and mechanisms of action.  Contributors discuss the role of tocotrienols in the treatment and prevention of cancer and in cardiovascular health, diabetes, and other hormone regulation by tocotrienols.

Contents:  Tocotrienols in Plants: Occurrence, biosynthesis, & function; Safety of unsaturated vitamin E tocotrienols & their isomers; Bioavailability & metabolism of tocotrienols; Bioavailability of tocotrienols & interference of their bioavailability by alpha-tocopherol supplementation; Alpha-tocopherol: a detriment to tocotrienol benefits; Antiangiogenic effects of tocotrienol; Mechanism of delta-tocotrienol on colorectal cancer; Targeted prostate cancer chemoprevention trial with tocotrienols; Delta-tocotrienols: demethylated vitamin E with hormetic function & therapeutic application in breast cancer; Mevalonate-suppressive tocotrienols for cancer chemoprevention; Potential of tocotrienols in lung cancer; Tocotrienols ans atherosclerosis: potential in cardioprotection; Tocotrienols: viable options for managing metabolic diseases; Tocotrienols as possible treatments for obesity; Tocotrienols, inflammation & cancer: how are they linked? 1-Modulating NF-kappaB activity by tocotrienols; Antioxidant action of tocotrienols; Tocotrienol in human pancreatic cancer; Tocotrienols in the treatment of dyslipidemia; Tocotrienols & vascular effects; Prolongevity effects of tocotrienols: trials in Caenorhabditis elegans; Anti-tyrosinase activity of tocotrienol in skin blemishes; Tocotrienols & bone health; Tocotrienol & physiology of reproduction; Tocotrienol & tocopherol in stress-induced gastric mucosal injury; Structural modification of tocotrienols to improve bioavailability; Index.

Barrie Tan, Ronald R Watson, Victor R Preedy, 2013, 377 p, illustrated.  ($210.00)  $160.00

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